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For example it seemed that if the expression level of ADAM33 is increased, it maintains its ability to inhibit α5β1 integrin-mediated cell migration, but loses it ability to inhibit α4β1-mediated cell migration (Huang, Brideges, and White, unpublished data). If ADAMs selectively titer integrin-mediated cell migration, they may do so in complex ways. For example, if cells in a population express multiple integrins that are capable of engaging multiple ECM substrates, the expression of an ADAM would not stop cell migration. Our finding that different ADAMs can selectively affect cell migration mediated by different integrins suggests that ADAMs could influence integrin-mediated migration events in interesting and complex ways. Although ADAMs and integrins may interact in neighboring cells (Eto et al., 2000), the fact that ADAM 12 inhibits α4β1-mediated migration of single cells (Figure 7) indicates that an ADAM can influence an integrin in the same cell.
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